Atlases Hub

Published in 2018

Neuroimage

Atlases of cortical parcellations (including subcortical regions) based on 150um multi-modal ex-vivo MRI data
(Liu C, et al, Neuroimage, 2018)

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Published in 2020

Nature Neuroscience

Most detailed white matter pathway atlas based on ultra-high resoultion multi-modal ex-vivo MRI data (80um, 64um and 50um)
(Liu C, et al, Nature Neuroscience, 2020)

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Published in 2021

Neuroimage

Population-based templates and analysis tools based on in-vivo data from 27 marmosets for neuroimaging and connectome studies.    
(Liu C, et al, Neuroimage, 2021)

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Version1 - Published in 2018

The Version-1 Focused on Cortical Parcellations


Liu C, et al. A digital 3D atlas of the marmoset brain based on multi-modal MRI. Neuroimage. 2018

Abstract The common marmoset (Callithrix jacchus) is a New-World monkey of growing interest in neuroscience. Magnetic resonance imaging (MRI) is an essential tool to unveil the anatomical and functional organization of the marmoset brain. To facilitate identification of regions of interest, it is desirable to register MR images to an atlas of the brain. However, currently available atlases of the marmoset brain are mainly based on 2D histological data, which are difficult to apply to 3D imaging techniques. Here, we constructed a 3D digital atlas based on high-resolution ex-vivo MRI images, including magnetization transfer ratio (a T1-like contrast), T2w images, and multi-shell diffusion MRI. Based on the multi-modal MRI images, we manually delineated 54 cortical areas and 16 subcortical regions on one hemisphere of the brain (the core version). The 54 cortical areas were merged into 13 larger cortical regions according to their locations to yield a coarse version of the atlas, and also parcellated into 106 sub-regions using a connectivity-based parcellation method to produce a refined atlas. Finally, we compared the new atlas set with existing histology atlases and demonstrated its applications in connectome studies, and in resting state and stimulus-based fMRI. The atlas set has been integrated into the widely-distributed neuroimaging data analysis software AFNI and SUMA, providing a readily usable multi-modal template space with multi-level anatomical labels (including labels from the Paxinos atlas) that can facilitate various neuroimaging studies of marmosets.

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Download the associated MRI Data (150um)
Version2 - Published in 2020

The Version-2 Focused on White Matter Pathways


Liu C, et al. A resource for detailed 3D mapping of white matter pathways in the marmoset brain. Nature Neuroscience. 2020

Abstract While the fundamental importance of the white matter in supporting neuronal communication is well known, a detailed description of its complex anatomy is not prominently featured in existing publications of primate brains. One main barrier is that existing neuroimaging data of the primate brain have either insufficient spatial resolution or image contrast to fully resolve white matter pathways. Here, we present an open resource that allows detailed descriptions of white matter structures and the trajectory of fiber-pathways in the marmoset brain. The resource includes 1) diffusion MRI (dMRI) data with the highest resolution available to date revealing white matter features never previously described; 2) a comprehensive 3D white matter atlas depicting fiber pathways that were either omitted or misidentified in previous atlases; 3) comprehensive fiber-pathway maps of cortical connections combining dMRI tractography and neuronal tracing data. Our data will facilitate studying brain connectivity and developing tractography algorithms in the primate brain.

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Download the associated MRI Data (80um, 64um and 50um)

Download All Tracing-guided Tracking Probilities Maps

Online-viewing Tracing-guided Tracking Probilities Maps Online-viewing the Merged Atlas (v2.0.1) with cortex_vH Online-viewing the Merged Atlas (v2.0.1) with cortex_vPaxinos
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Version3 - Published in 2021

The Version-3 Focused on Population-based Standard Templates

Liu C, et al. Marmoset Brain Mapping V3: Population multi-modal standard volumetric and surface-based templates. 2021

Abstract The standard anatomical brain template provides a common space and coordinate system for visualizing and analyzing neuroimaging data from large cohorts of subjects. Previous templates and atlases for the common marmoset brain were either based on data from a single individual or lacked essential functionalities for neuroimaging analysis. Here, we present new population-based in-vivo standard templates and tools derived from multi-modal data of 27 marmosets, including multiple types of T1w and T2w contrast images, DTI contrasts, and large field-of-view MRI and CT images. We performed multi-atlas labeling of anatomical structures on the new templates and constructed highly accurate tissue-type segmentation maps to facilitate volumetric studies. We built fully featured brain surfaces and cortical flat maps to facilitate 3D visualization and surface-based analyses, which are compatible with most surface analyzing tools, including FreeSurfer, AFNI/SUMA, and the Connectome Workbench. Analysis of the MRI and CT datasets revealed significant variations in brain shapes, sizes, and regional volumes of brain structures, highlighting substantial individual variabilities in the marmoset population. Thus, our population-based template and associated tools provide a versatile analysis platform and standard coordinate system for a wide range of MRI and connectome studies of common marmosets.

Download the V3 Atlases